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What the FDA labels say about taking them together

Etoposide and ondansetron

Ondansetron's FDA label of January 8, 2026 names etoposide in its drug interactions section; the etoposide labels PlainMeds reads (3) do not name ondansetron. The ondansetron label: “Chemotherapy Carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.”

Check it at the source: the etoposide FDA label on DailyMed (effective September 14, 2023, Hikma Pharmaceuticals USA Inc.); the ondansetron FDA label on DailyMed (effective January 8, 2026, Glenmark Pharmaceuticals Inc., USA).

What does the etoposide label say about ondansetron?

Etoposide's label (effective September 14, 2023) and its 2 other brand-application labels do not name ondansetron in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Etoposide), Hikma Pharmaceuticals USA Inc., effective September 14, 2023 (SPL set 6dfedeff-a807-4405-a482-2f7109ad31c9), via openFDA; the full label on DailyMed

What does the ondansetron label say about etoposide?

Ondansetron label, drug interactions

Chemotherapy Carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.

Source: FDA drug label (Ondansetron), Glenmark Pharmaceuticals Inc., USA, effective January 8, 2026 (SPL set eee5217a-eba8-463a-812d-bf3c66f0934f), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

6Etoposide generic labelers
77Ondansetron generic labelers
EtoposideOndansetron
Labeled forLung cancerNausea and vomiting
Boxed warningYesNo
Pharmacy cost (NADAC)n/a$0.0582 per tablet 4 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?