What the FDA labels say about taking them together
Etonogestrel and rifabutin
Etonogestrel's FDA label of May 28, 2026 names rifabutin in its drug interactions section; the rifabutin label PlainMeds reads does not name etonogestrel. The etonogestrel label: “… bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.”
Check it at the source: the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC); the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.).
What does the etonogestrel label say about rifabutin?
Etonogestrel label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
What does the rifabutin label say about etonogestrel?
Rifabutin's label (effective September 1, 2026) does not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etonogestrel | Rifabutin | |
|---|---|---|
| Labeled for | Birth control | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $8.14 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once