What the FDA labels say about taking them together
Etonogestrel and ketoconazole
Etonogestrel's FDA label of May 28, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name etonogestrel. The etonogestrel label: “… inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the serum concentrations of progestins, including etonogestrel.”
Check it at the source: the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the etonogestrel label say about ketoconazole?
Etonogestrel label, drug interactionsSubstances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the serum concentrations of progestins, including etonogestrel.
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
What does the ketoconazole label say about etonogestrel?
Ketoconazole's label (effective January 28, 2026) does not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etonogestrel | Ketoconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once