What the FDA labels say about taking them together
Etonogestrel and fluconazole
Etonogestrel's FDA label of May 28, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name etonogestrel. The etonogestrel label: “Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may …”
Check it at the source: the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the etonogestrel label say about fluconazole?
Etonogestrel label, drug interactionsSubstances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the serum concentrations of progestins, including etonogestrel.
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
What does the fluconazole label say about etonogestrel?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etonogestrel | Fluconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once