What the FDA labels say about taking them together
Aprepitant and etonogestrel
Etonogestrel's FDA label of May 28, 2026 names aprepitant in its drug interactions section; the aprepitant labels PlainMeds reads (3) do not name etonogestrel. The etonogestrel label: “… griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC).
What does the aprepitant label say about etonogestrel?
Aprepitant's label (effective July 5, 2024) and its 2 other brand-application labels do not name etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the etonogestrel label say about aprepitant?
Etonogestrel label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Etonogestrel | |
|---|---|---|
| Labeled for | Nausea and vomiting | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once