What the FDA labels say about taking them together
Etodolac and lithium
Etodolac's FDA label of July 16, 2026 names lithium in its drug interactions section; lithium's label does not name etodolac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The etodolac label: “Lithium NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.”
Check it at the source: the etodolac FDA label on DailyMed (effective July 16, 2026, Aurobindo Pharma Limited); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the etodolac label say about lithium?
Etodolac label, drug interactionsLithium NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.
Source: FDA drug label (Etodolac), Aurobindo Pharma Limited, effective July 16, 2026 (SPL set c74c3c56-a5ac-40b4-974b-c4f4b05c5df9), via openFDA; the full label on DailyMed
What does the lithium label say about etodolac?
Lithium's label does not name etodolac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Lithium label, drug interactionsDiuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.
Lithium label, drug interactionsReduce lithium dosage based on serum lithium concentration and clinical response [see Dosage and Administration ( 2.3 ), Warning and Precautions ( 5.3 )]. Non-Steroidal Anti-inflammatory Drugs (NSAID)
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etodolac | Lithium | |
|---|---|---|
| Labeled for | Pain, Osteoarthritis, Rheumatoid arthritis | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.262 per tablet 400 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once