What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and theophylline
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Concomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the ethinyl estradiol/segesterone label say about theophylline?
Ethinyl estradiol/segesterone label, drug interactionsConcomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs (eg, cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole).
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the theophylline label say about ethinyl estradiol/segesterone?
Theophylline's label (effective March 10, 2026) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Theophylline | |
|---|---|---|
| Labeled for | Birth control | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once