What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and temazepam
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names temazepam in its drug interactions section; the temazepam label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Other Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the temazepam FDA label on DailyMed (effective June 9, 2026).
What does the ethinyl estradiol/segesterone label say about temazepam?
Ethinyl estradiol/segesterone label, drug interactionsOther Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the temazepam label say about ethinyl estradiol/segesterone?
Temazepam's label (effective June 9, 2026) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (RESTORIL), SpecGx LLC, effective June 9, 2026 (SPL set bc56f7fd-1aaf-48ff-8aa7-d467e59e1015), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Temazepam | |
|---|---|---|
| Labeled for | Birth control | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.0767 per capsule 15 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once