What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and salicylic acid
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names salicylic acid in its drug interactions section; the salicylic acid label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Other Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the salicylic acid FDA label on DailyMed (effective October 22, 2024).
What does the ethinyl estradiol/segesterone label say about salicylic acid?
Ethinyl estradiol/segesterone label, drug interactionsOther Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the salicylic acid label say about ethinyl estradiol/segesterone?
Salicylic acid's label (effective October 22, 2024) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (bareMinerals Blemish Rescue Skin-Clearing Loose Foundation Fair 1C), Orveon Global US LLC, effective October 22, 2024 (SPL set 139e2d26-76de-4ad3-a6e6-7465bf5987ad), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Salicylic acid | |
|---|---|---|
| Labeled for | Birth control | Acne, Pain, Psoriasis |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.102 per patch Callus removers patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once