What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and morphine
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Other Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the ethinyl estradiol/segesterone label say about morphine?
Ethinyl estradiol/segesterone label, drug interactionsOther Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the morphine label say about ethinyl estradiol/segesterone?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Morphine | |
|---|---|---|
| Labeled for | Birth control | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once