What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and lamotrigine
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “Clinical effect; Concomitant use of CHCs with lamotrigine may significantly decrease systemic exposure of lamotrigine due to induction of lamotrigine glucuronidation.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the ethinyl estradiol/segesterone label say about lamotrigine?
Ethinyl estradiol/segesterone label, drug interactionsClinical effect; Concomitant use of CHCs with lamotrigine may significantly decrease systemic exposure of lamotrigine due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the lamotrigine label say about ethinyl estradiol/segesterone?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once