What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and ketoconazole
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase systemic exposure of the estrogen and/or progestin component of ANNOVERA.”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the ethinyl estradiol/segesterone label say about ketoconazole?
Ethinyl estradiol/segesterone label, drug interactionsCYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase systemic exposure of the estrogen and/or progestin component of ANNOVERA.
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the ketoconazole label say about ethinyl estradiol/segesterone?
Ketoconazole's label (effective January 28, 2026) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Ketoconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once