What the FDA labels say about taking them together
Ethinyl estradiol/segesterone and etravirine
Ethinyl estradiol/segesterone's FDA label of April 23, 2025 names etravirine in its drug interactions section; the etravirine label PlainMeds reads does not name ethinyl estradiol/segesterone. The ethinyl estradiol/segesterone label: “… inhibitors and with other non-nucleoside reverse transcriptase inhibitors (eg, etravirine).”
Check it at the source: the ethinyl estradiol/segesterone FDA label on DailyMed (effective April 23, 2025); the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP).
What does the ethinyl estradiol/segesterone label say about etravirine?
Ethinyl estradiol/segesterone label, drug interactionsIn contrast, significant increases in systemic exposure of estrogen and/or progestin have been noted when CHCs are co-administered with certain other HIV protease inhibitors (eg, indinavir and atazanavir/ritonavir) and with other non-nucleoside reverse transcriptase inhibitors (eg, etravirine).
Source: FDA drug label (Annovera), Mayne Pharma, effective April 23, 2025 (SPL set eb18194f-2021-41fa-8bdf-31e0c0eb646b), via openFDA; the full label on DailyMed
What does the etravirine label say about ethinyl estradiol/segesterone?
Etravirine's label (effective August 15, 2023) does not name ethinyl estradiol/segesterone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/segesterone | Etravirine | |
|---|---|---|
| Labeled for | Birth control | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2,315.29 per ring Annovera vaginal ring | $9.94 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once