What the FDA labels say about taking them together
Ethinyl estradiol/norgestimate and tizanidine
Ethinyl estradiol/norgestimate's FDA label of February 6, 2026 names tizanidine in its drug interactions section; the tizanidine labels PlainMeds reads (3) do not name ethinyl estradiol/norgestimate. The ethinyl estradiol/norgestimate label: “COCs containing EE may inhibit the metabolism of other compounds and increase their plasma concentrations.”
Check it at the source: the ethinyl estradiol/norgestimate FDA label on DailyMed (effective February 6, 2026, Glenmark Pharmaceuticals Inc., USA); the tizanidine FDA label on DailyMed (effective January 2, 2026, Legacy Pharma USA, Inc.).
What does the ethinyl estradiol/norgestimate label say about tizanidine?
Ethinyl estradiol/norgestimate label, drug interactionsCOCs containing EE may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Source: FDA drug label (Norgestimate and Ethinyl Estradiol), Glenmark Pharmaceuticals Inc., USA, effective February 6, 2026 (SPL set 8b247e46-203e-4f5b-b5a7-cbd57341c735), via openFDA; the full label on DailyMed
What does the tizanidine label say about ethinyl estradiol/norgestimate?
Tizanidine's label (effective January 2, 2026) and its 2 other brand-application labels do not name ethinyl estradiol/norgestimate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zanaflex), Legacy Pharma USA, Inc., effective January 2, 2026 (SPL set 60c27d35-7349-4fc6-86ad-70fffdbe3e08), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norgestimate | Tizanidine | |
|---|---|---|
| Labeled for | Acne, Birth control | Muscle spasms and spasticity |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.115 per tablet 0.25-0.035 mg tablet | $0.0331 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once