What the FDA labels say about taking them together
Ethinyl estradiol/norgestimate and morphine
Ethinyl estradiol/norgestimate's FDA label of February 6, 2026 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name ethinyl estradiol/norgestimate. The ethinyl estradiol/norgestimate label: “COCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.”
Check it at the source: the ethinyl estradiol/norgestimate FDA label on DailyMed (effective February 6, 2026, Glenmark Pharmaceuticals Inc., USA); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the ethinyl estradiol/norgestimate label say about morphine?
Ethinyl estradiol/norgestimate label, drug interactionsCOCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.
Source: FDA drug label (Norgestimate and Ethinyl Estradiol), Glenmark Pharmaceuticals Inc., USA, effective February 6, 2026 (SPL set 8b247e46-203e-4f5b-b5a7-cbd57341c735), via openFDA; the full label on DailyMed
What does the morphine label say about ethinyl estradiol/norgestimate?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/norgestimate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norgestimate | Morphine | |
|---|---|---|
| Labeled for | Acne, Birth control | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.115 per tablet 0.25-0.035 mg tablet | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once