What the FDA labels say about taking them together
Colesevelam and ethinyl estradiol/norgestimate
Ethinyl estradiol/norgestimate's FDA label of February 6, 2026 names colesevelam in its drug interactions section; the colesevelam label PlainMeds reads does not name ethinyl estradiol/norgestimate. The ethinyl estradiol/norgestimate label: “Colesevelam, a bile acid sequestrant, given together with a COC, has been shown to significantly decrease the AUC of EE.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the ethinyl estradiol/norgestimate FDA label on DailyMed (effective February 6, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the colesevelam label say about ethinyl estradiol/norgestimate?
Colesevelam's label (effective December 28, 2023) does not name ethinyl estradiol/norgestimate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/norgestimate label say about colesevelam?
Ethinyl estradiol/norgestimate label, drug interactionsColesevelam, a bile acid sequestrant, given together with a COC, has been shown to significantly decrease the AUC of EE.
Source: FDA drug label (Norgestimate and Ethinyl Estradiol), Glenmark Pharmaceuticals Inc., USA, effective February 6, 2026 (SPL set 8b247e46-203e-4f5b-b5a7-cbd57341c735), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Ethinyl estradiol/norgestimate | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | Acne, Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $0.115 per tablet 0.25-0.035 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once