What the FDA labels say about taking them together
Ethinyl estradiol/norethindrone and topiramate
Ethinyl estradiol/norethindrone's FDA label (Femlyv) of September 3, 2025 names topiramate in its drug interactions section; the topiramate labels PlainMeds reads (4) do not name ethinyl estradiol/norethindrone. The ethinyl estradiol/norethindrone label: “… carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate and products containing St. John’s wort.”
Check it at the source: the ethinyl estradiol/norethindrone FDA label on DailyMed (effective November 18, 2025, Lupin Pharmaceuticals, Inc.); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the ethinyl estradiol/norethindrone label say about topiramate?
Femlyv label (Millicent US, Inc., September 3, 2025), drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate and products containing St. John’s wort.
Source: FDA drug label (Femlyv, NDA218718), Millicent US, Inc., effective September 3, 2025 (SPL set a3c99fc1-9b05-4f0a-ad00-5e3e206302c9), via openFDA
Source: FDA drug label (Blisovi Fe 1/20), Lupin Pharmaceuticals, Inc., effective November 18, 2025 (SPL set ddbb5d60-cacf-4672-935d-86d668287992), via openFDA; the full label on DailyMed
What does the topiramate label say about ethinyl estradiol/norethindrone?
Topiramate's label (effective June 1, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norethindrone | Topiramate | |
|---|---|---|
| Labeled for | Birth control, Osteoporosis, Menopause symptoms, Acne | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.181 per tablet 21 1-20 tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once