What the FDA labels say about taking them together
Ethinyl estradiol/norethindrone and nicotine
Ethinyl estradiol/norethindrone's FDA label (Femlyv) of September 3, 2025 names nicotine in its warnings and precautions section; the nicotine labels PlainMeds reads (2) do not name ethinyl estradiol/norethindrone. The ethinyl estradiol/norethindrone label: “In addition to cigarettes, use of other nicotine-containing products – including cigars, smokeless tobacco, hookah tobacco, e-cigarettes, and nicotine replacement therapy – may also increase the risk of serious …”
Check it at the source: the ethinyl estradiol/norethindrone FDA label on DailyMed (effective November 18, 2025, Lupin Pharmaceuticals, Inc.); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the ethinyl estradiol/norethindrone label say about nicotine?
Femlyv label (Millicent US, Inc., September 3, 2025), warnings and precautionsIn addition to cigarettes, use of other nicotine-containing products – including cigars, smokeless tobacco, hookah tobacco, e-cigarettes, and nicotine replacement therapy – may also increase the risk of serious cardiovascular events from CHC use.
Source: FDA drug label (Femlyv, NDA218718), Millicent US, Inc., effective September 3, 2025 (SPL set a3c99fc1-9b05-4f0a-ad00-5e3e206302c9), via openFDA
Source: FDA drug label (Blisovi Fe 1/20), Lupin Pharmaceuticals, Inc., effective November 18, 2025 (SPL set ddbb5d60-cacf-4672-935d-86d668287992), via openFDA; the full label on DailyMed
What does the nicotine label say about ethinyl estradiol/norethindrone?
Nicotine's label (effective July 25, 2024) and its 1 other brand-application label do not name ethinyl estradiol/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norethindrone | Nicotine | |
|---|---|---|
| Labeled for | Birth control, Osteoporosis, Menopause symptoms, Acne | Quitting smoking |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.181 per tablet 21 1-20 tablet | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once