What the FDA labels say about taking them together
Ethinyl estradiol/norethindrone and lamotrigine
Ethinyl estradiol/norethindrone's FDA label (Femlyv) of September 3, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name ethinyl estradiol/norethindrone. The ethinyl estradiol/norethindrone label: “COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the ethinyl estradiol/norethindrone FDA label on DailyMed (effective November 18, 2025, Lupin Pharmaceuticals, Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the ethinyl estradiol/norethindrone label say about lamotrigine?
Femlyv label (Millicent US, Inc., September 3, 2025), drug interactionsCOCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Femlyv, NDA218718), Millicent US, Inc., effective September 3, 2025 (SPL set a3c99fc1-9b05-4f0a-ad00-5e3e206302c9), via openFDA
Source: FDA drug label (Blisovi Fe 1/20), Lupin Pharmaceuticals, Inc., effective November 18, 2025 (SPL set ddbb5d60-cacf-4672-935d-86d668287992), via openFDA; the full label on DailyMed
What does the lamotrigine label say about ethinyl estradiol/norethindrone?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name ethinyl estradiol/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norethindrone | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control, Osteoporosis, Menopause symptoms, Acne | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.181 per tablet 21 1-20 tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once