What the FDA labels say about taking them together
Ascorbic acid and ethinyl estradiol/norethindrone
Ethinyl estradiol/norethindrone's FDA label (Femlyv) of September 3, 2025 names ascorbic acid in its drug interactions section; the ascorbic acid label PlainMeds reads does not name ethinyl estradiol/norethindrone. The ethinyl estradiol/norethindrone label: “Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.”
Check it at the source: the ascorbic acid FDA label on DailyMed (effective May 29, 2026, McGuff Pharmaceuticals, Inc.); the ethinyl estradiol/norethindrone FDA label on DailyMed (effective November 18, 2025, Lupin Pharmaceuticals, Inc.).
What does the ascorbic acid label say about ethinyl estradiol/norethindrone?
Ascorbic acid's label (effective May 29, 2026) does not name ethinyl estradiol/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ascor), McGuff Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 388aad52-fc01-4784-9791-1dbc80c69306), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/norethindrone label say about ascorbic acid?
Femlyv label (Millicent US, Inc., September 3, 2025), drug interactionsAscorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (Femlyv, NDA218718), Millicent US, Inc., effective September 3, 2025 (SPL set a3c99fc1-9b05-4f0a-ad00-5e3e206302c9), via openFDA
Source: FDA drug label (Blisovi Fe 1/20), Lupin Pharmaceuticals, Inc., effective November 18, 2025 (SPL set ddbb5d60-cacf-4672-935d-86d668287992), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ascorbic acid | Ethinyl estradiol/norethindrone | |
|---|---|---|
| Labeled for | n/a | Birth control, Osteoporosis, Menopause symptoms, Acne |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.181 per tablet 21 1-20 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once