What the FDA labels say about taking them together
Acetaminophen and ethinyl estradiol/norethindrone
Ethinyl estradiol/norethindrone's FDA label (Femlyv) of September 3, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name ethinyl estradiol/norethindrone. The ethinyl estradiol/norethindrone label: “Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the ethinyl estradiol/norethindrone FDA label on DailyMed (effective November 18, 2025, Lupin Pharmaceuticals, Inc.).
What does the acetaminophen label say about ethinyl estradiol/norethindrone?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name ethinyl estradiol/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/norethindrone label say about acetaminophen?
Femlyv label (Millicent US, Inc., September 3, 2025), drug interactionsAscorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (Femlyv, NDA218718), Millicent US, Inc., effective September 3, 2025 (SPL set a3c99fc1-9b05-4f0a-ad00-5e3e206302c9), via openFDA
Source: FDA drug label (Blisovi Fe 1/20), Lupin Pharmaceuticals, Inc., effective November 18, 2025 (SPL set ddbb5d60-cacf-4672-935d-86d668287992), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Ethinyl estradiol/norethindrone | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Birth control, Osteoporosis, Menopause symptoms, Acne |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $0.181 per tablet 21 1-20 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once