What the FDA labels say about taking them together
Ethinyl estradiol/norelgestromin and prednisolone
Ethinyl estradiol/norelgestromin's FDA label of April 16, 2026 names prednisolone in its drug interactions section; the prednisolone labels PlainMeds reads (4) do not name ethinyl estradiol/norelgestromin. The ethinyl estradiol/norelgestromin label: “Concomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs.”
Check it at the source: the ethinyl estradiol/norelgestromin FDA label on DailyMed (effective April 16, 2026, Zydus Pharmaceuticals USA Inc.); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the ethinyl estradiol/norelgestromin label say about prednisolone?
Ethinyl estradiol/norelgestromin label, drug interactionsContraceptives on Other Drugs CHCs containing EE may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Gwyn Lo label (Viatris Specialty LLC, July 6, 2026), drug interactionsConcomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole).
Source: FDA drug label (Gwyn Lo, NDA219990), Viatris Specialty LLC, effective July 6, 2026 (SPL set e92741f4-87fe-429f-b5b5-c558ed5f4fa9), via openFDA
Source: FDA drug label (norelgestromin and ethinyl estradiol), Zydus Pharmaceuticals USA Inc., effective April 16, 2026 (SPL set 10fa1458-c8ed-4197-922a-1ba7271d2b02), via openFDA; the full label on DailyMed
What does the prednisolone label say about ethinyl estradiol/norelgestromin?
Prednisolone's label (effective June 25, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/norelgestromin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norelgestromin | Prednisolone | |
|---|---|---|
| Labeled for | Birth control | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $37.16 per patch 150-35 mcg/day patch | $4.72 per mL 1% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once