What the FDA labels say about taking them together
Ethinyl estradiol/norelgestromin and morphine
Ethinyl estradiol/norelgestromin's FDA label of April 16, 2026 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name ethinyl estradiol/norelgestromin. The ethinyl estradiol/norelgestromin label: “CHCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, and temazepam.”
Check it at the source: the ethinyl estradiol/norelgestromin FDA label on DailyMed (effective April 16, 2026, Zydus Pharmaceuticals USA Inc.); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the ethinyl estradiol/norelgestromin label say about morphine?
Ethinyl estradiol/norelgestromin label, drug interactionsCHCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, and temazepam.
Gwyn Lo label (Viatris Specialty LLC, July 6, 2026), drug interactionsOther Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Source: FDA drug label (Gwyn Lo, NDA219990), Viatris Specialty LLC, effective July 6, 2026 (SPL set e92741f4-87fe-429f-b5b5-c558ed5f4fa9), via openFDA
Source: FDA drug label (norelgestromin and ethinyl estradiol), Zydus Pharmaceuticals USA Inc., effective April 16, 2026 (SPL set 10fa1458-c8ed-4197-922a-1ba7271d2b02), via openFDA; the full label on DailyMed
What does the morphine label say about ethinyl estradiol/norelgestromin?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/norelgestromin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norelgestromin | Morphine | |
|---|---|---|
| Labeled for | Birth control | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $37.16 per patch 150-35 mcg/day patch | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once