What the FDA labels say about taking them together
Ethinyl estradiol/norelgestromin and lamotrigine
Ethinyl estradiol/norelgestromin's FDA label of April 16, 2026 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name ethinyl estradiol/norelgestromin. The ethinyl estradiol/norelgestromin label: “Significant decrease in plasma concentration of lamotrigine has been shown, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the ethinyl estradiol/norelgestromin FDA label on DailyMed (effective April 16, 2026, Zydus Pharmaceuticals USA Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the ethinyl estradiol/norelgestromin label say about lamotrigine?
Ethinyl estradiol/norelgestromin label, drug interactionsSignificant decrease in plasma concentration of lamotrigine has been shown, likely due to induction of lamotrigine glucuronidation.
Gwyn Lo label (Viatris Specialty LLC, July 6, 2026), drug interactionsSignificant Drug Interaction Information for Drugs Co-Administered with CHCs Lamotrigine Clinical effect
Source: FDA drug label (Gwyn Lo, NDA219990), Viatris Specialty LLC, effective July 6, 2026 (SPL set e92741f4-87fe-429f-b5b5-c558ed5f4fa9), via openFDA
Source: FDA drug label (norelgestromin and ethinyl estradiol), Zydus Pharmaceuticals USA Inc., effective April 16, 2026 (SPL set 10fa1458-c8ed-4197-922a-1ba7271d2b02), via openFDA; the full label on DailyMed
What does the lamotrigine label say about ethinyl estradiol/norelgestromin?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name ethinyl estradiol/norelgestromin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norelgestromin | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $37.16 per patch 150-35 mcg/day patch | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once