What the FDA labels say about taking them together
Ethinyl estradiol/norelgestromin and fluconazole
Ethinyl estradiol/norelgestromin's FDA label of April 16, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name ethinyl estradiol/norelgestromin. The ethinyl estradiol/norelgestromin label: “CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.”
Check it at the source: the ethinyl estradiol/norelgestromin FDA label on DailyMed (effective April 16, 2026, Zydus Pharmaceuticals USA Inc.); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the ethinyl estradiol/norelgestromin label say about fluconazole?
Ethinyl estradiol/norelgestromin label, drug interactionsCYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.
Source: FDA drug label (Gwyn Lo, NDA219990), Viatris Specialty LLC, effective July 6, 2026 (SPL set e92741f4-87fe-429f-b5b5-c558ed5f4fa9), via openFDA
Source: FDA drug label (norelgestromin and ethinyl estradiol), Zydus Pharmaceuticals USA Inc., effective April 16, 2026 (SPL set 10fa1458-c8ed-4197-922a-1ba7271d2b02), via openFDA; the full label on DailyMed
What does the fluconazole label say about ethinyl estradiol/norelgestromin?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name ethinyl estradiol/norelgestromin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norelgestromin | Fluconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $37.16 per patch 150-35 mcg/day patch | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once