What the FDA labels say about taking them together
Ethinyl estradiol/levonorgestrel and tizanidine
Ethinyl estradiol/levonorgestrel's FDA label of August 27, 2026 names tizanidine in its drug interactions section; the tizanidine labels PlainMeds reads (3) do not name ethinyl estradiol/levonorgestrel. The ethinyl estradiol/levonorgestrel label: “Concomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs.”
Check it at the source: the ethinyl estradiol/levonorgestrel FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the tizanidine FDA label on DailyMed (effective January 2, 2026, Legacy Pharma USA, Inc.).
What does the ethinyl estradiol/levonorgestrel label say about tizanidine?
Ethinyl estradiol/levonorgestrel label, drug interactionsConcomitant use with ethinyl estradiol-containing CHCs may increase systemic exposure of other drugs (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole).
Balcoltra label (Avion Pharmaceuticals, December 5, 2025), drug interactionsContraceptives on Other Drugs Combined oral contraceptives containing EE may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Source: FDA drug label (Balcoltra, NDA208612), Avion Pharmaceuticals, effective December 5, 2025 (SPL set 752ab698-4b48-4614-8016-d1d33ee7c007), via openFDA
Source: FDA drug label (Tyblume), Exeltis USA, Inc., effective August 27, 2026 (SPL set b2482d51-d606-4aaa-8af4-19e4fe2f8872), via openFDA; the full label on DailyMed
What does the tizanidine label say about ethinyl estradiol/levonorgestrel?
Tizanidine's label (effective January 2, 2026) and its 2 other brand-application labels do not name ethinyl estradiol/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zanaflex), Legacy Pharma USA, Inc., effective January 2, 2026 (SPL set 60c27d35-7349-4fc6-86ad-70fffdbe3e08), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/levonorgestrel | Tizanidine | |
|---|---|---|
| Labeled for | Birth control | Muscle spasms and spasticity |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.154 per tablet 28 tablet | $0.0331 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once