What the FDA labels say about taking them together
Ethinyl estradiol/levonorgestrel and morphine
Ethinyl estradiol/levonorgestrel's FDA label of August 27, 2026 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name ethinyl estradiol/levonorgestrel. The ethinyl estradiol/levonorgestrel label: “Other Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.”
Check it at the source: the ethinyl estradiol/levonorgestrel FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the ethinyl estradiol/levonorgestrel label say about morphine?
Ethinyl estradiol/levonorgestrel label, drug interactionsOther Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Balcoltra label (Avion Pharmaceuticals, December 5, 2025), drug interactionsCombined oral contraceptives have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.
Source: FDA drug label (Balcoltra, NDA208612), Avion Pharmaceuticals, effective December 5, 2025 (SPL set 752ab698-4b48-4614-8016-d1d33ee7c007), via openFDA
Source: FDA drug label (Tyblume), Exeltis USA, Inc., effective August 27, 2026 (SPL set b2482d51-d606-4aaa-8af4-19e4fe2f8872), via openFDA; the full label on DailyMed
What does the morphine label say about ethinyl estradiol/levonorgestrel?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/levonorgestrel | Morphine | |
|---|---|---|
| Labeled for | Birth control | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.154 per tablet 28 tablet | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once