What the FDA labels say about taking them together
Ascorbic acid and ethinyl estradiol/levonorgestrel
Ethinyl estradiol/levonorgestrel's FDA label of August 27, 2026 names ascorbic acid in its drug interactions section; the ascorbic acid label PlainMeds reads does not name ethinyl estradiol/levonorgestrel. The ethinyl estradiol/levonorgestrel label: “Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.”
Check it at the source: the ascorbic acid FDA label on DailyMed (effective May 29, 2026, McGuff Pharmaceuticals, Inc.); the ethinyl estradiol/levonorgestrel FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.).
What does the ascorbic acid label say about ethinyl estradiol/levonorgestrel?
Ascorbic acid's label (effective May 29, 2026) does not name ethinyl estradiol/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ascor), McGuff Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 388aad52-fc01-4784-9791-1dbc80c69306), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/levonorgestrel label say about ascorbic acid?
Ethinyl estradiol/levonorgestrel label, drug interactionsAscorbic acid and acetaminophen may increase systemic exposure of ethinyl estradiol, possibly by inhibition of conjugation.
Source: FDA drug label (Balcoltra, NDA208612), Avion Pharmaceuticals, effective December 5, 2025 (SPL set 752ab698-4b48-4614-8016-d1d33ee7c007), via openFDA
Source: FDA drug label (Tyblume), Exeltis USA, Inc., effective August 27, 2026 (SPL set b2482d51-d606-4aaa-8af4-19e4fe2f8872), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ascorbic acid | Ethinyl estradiol/levonorgestrel | |
|---|---|---|
| Labeled for | n/a | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.154 per tablet 28 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once