What the FDA labels say about taking them together
Ethinyl estradiol/ferrous fumarate/norethindrone and topiramate
Ethinyl estradiol/ferrous fumarate/norethindrone's FDA label (Lo Loestrin Fe) of March 7, 2025 names topiramate in its drug interactions section; the topiramate labels PlainMeds reads (4) do not name ethinyl estradiol/ferrous fumarate/norethindrone. The ethinyl estradiol/ferrous fumarate/norethindrone label: “… carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate and products containing St. John’s wort.”
Check it at the source: the ethinyl estradiol/ferrous fumarate/norethindrone FDA label on DailyMed (effective May 21, 2026, PD-Rx Pharmaceuticals, Inc.); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the ethinyl estradiol/ferrous fumarate/norethindrone label say about topiramate?
Lo Loestrin Fe label (Allergan, Inc., March 7, 2025), drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: barbiturates bosentan carbamazepine felbamate griseofulvin oxcarbazepine phenytoin rifampin St. John’s wort topiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors:
Taytulla label (Allergan, Inc., October 25, 2024), drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate and products containing St. John’s wort.
Source: FDA drug label (Lo Loestrin Fe, NDA022501), Allergan, Inc., effective March 7, 2025 (SPL set c33072cf-625d-4b4a-981e-ec049c5d78aa), via openFDA
Source: FDA drug label (Taytulla, NDA204426), Allergan, Inc., effective October 25, 2024 (SPL set 2fa8e8dc-f7b0-429a-b554-0e3c4291c92c), via openFDA
Source: FDA drug label (Junel Fe 28 Day), ANDA076081 (Barr), as published by PD-Rx Pharmaceuticals, Inc., effective May 21, 2026 (SPL set 93a2f8c9-3550-42ec-8f76-3ac9badf4bb2), via openFDA; the full label on DailyMed
What does the topiramate label say about ethinyl estradiol/ferrous fumarate/norethindrone?
Topiramate's label (effective June 1, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ferrous fumarate/norethindrone | Topiramate | |
|---|---|---|
| Labeled for | Birth control, Acne | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.142 per tablet 1.5-30 tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once