What the FDA labels say about taking them together
Ethinyl estradiol/ferrous fumarate/norethindrone and rifampin
Ethinyl estradiol/ferrous fumarate/norethindrone's FDA label (Lo Loestrin Fe) of March 7, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name ethinyl estradiol/ferrous fumarate/norethindrone. The ethinyl estradiol/ferrous fumarate/norethindrone label: “… barbiturates bosentan carbamazepine felbamate griseofulvin oxcarbazepine phenytoin rifampin St. John’s wort topiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors:”
Check it at the source: the ethinyl estradiol/ferrous fumarate/norethindrone FDA label on DailyMed (effective May 21, 2026, PD-Rx Pharmaceuticals, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the ethinyl estradiol/ferrous fumarate/norethindrone label say about rifampin?
Lo Loestrin Fe label (Allergan, Inc., March 7, 2025), drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: barbiturates bosentan carbamazepine felbamate griseofulvin oxcarbazepine phenytoin rifampin St. John’s wort topiramate HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors:
Source: FDA drug label (Lo Loestrin Fe, NDA022501), Allergan, Inc., effective March 7, 2025 (SPL set c33072cf-625d-4b4a-981e-ec049c5d78aa), via openFDA
Source: FDA drug label (Junel Fe 28 Day), ANDA076081 (Barr), as published by PD-Rx Pharmaceuticals, Inc., effective May 21, 2026 (SPL set 93a2f8c9-3550-42ec-8f76-3ac9badf4bb2), via openFDA; the full label on DailyMed
What does the rifampin label say about ethinyl estradiol/ferrous fumarate/norethindrone?
Rifampin's label (effective February 11, 2026) does not name ethinyl estradiol/ferrous fumarate/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ferrous fumarate/norethindrone | Rifampin | |
|---|---|---|
| Labeled for | Birth control, Acne | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.142 per tablet 1.5-30 tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once