What the FDA labels say about taking them together
Ethinyl estradiol/ferrous fumarate/norethindrone and lamotrigine
Ethinyl estradiol/ferrous fumarate/norethindrone's FDA label (Lo Loestrin Fe) of March 7, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name ethinyl estradiol/ferrous fumarate/norethindrone. The ethinyl estradiol/ferrous fumarate/norethindrone label: “COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the ethinyl estradiol/ferrous fumarate/norethindrone FDA label on DailyMed (effective May 21, 2026, PD-Rx Pharmaceuticals, Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the ethinyl estradiol/ferrous fumarate/norethindrone label say about lamotrigine?
Lo Loestrin Fe label (Allergan, Inc., March 7, 2025), drug interactionsCOCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Lo Loestrin Fe, NDA022501), Allergan, Inc., effective March 7, 2025 (SPL set c33072cf-625d-4b4a-981e-ec049c5d78aa), via openFDA
Source: FDA drug label (Junel Fe 28 Day), ANDA076081 (Barr), as published by PD-Rx Pharmaceuticals, Inc., effective May 21, 2026 (SPL set 93a2f8c9-3550-42ec-8f76-3ac9badf4bb2), via openFDA; the full label on DailyMed
What does the lamotrigine label say about ethinyl estradiol/ferrous fumarate/norethindrone?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ferrous fumarate/norethindrone | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control, Acne | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.142 per tablet 1.5-30 tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once