What the FDA labels say about taking them together
Ethinyl estradiol/ferrous fumarate/levonorgestrel and rifabutin
Ethinyl estradiol/ferrous fumarate/levonorgestrel's FDA label of October 18, 2024 names rifabutin in its drug interactions section; the rifabutin label PlainMeds reads does not name ethinyl estradiol/ferrous fumarate/levonorgestrel. The ethinyl estradiol/ferrous fumarate/levonorgestrel label: “… bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.”
Check it at the source: the ethinyl estradiol/ferrous fumarate/levonorgestrel FDA label on DailyMed (effective October 18, 2024, Xiromed, LLC); the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.).
What does the ethinyl estradiol/ferrous fumarate/levonorgestrel label say about rifabutin?
Ethinyl estradiol/ferrous fumarate/levonorgestrel label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.
Source: FDA drug label (Joyeaux), Xiromed, LLC, effective October 18, 2024 (SPL set 655b2c93-cfae-d44f-c128-c816bbd88e45), via openFDA; the full label on DailyMed
What does the rifabutin label say about ethinyl estradiol/ferrous fumarate/levonorgestrel?
Rifabutin's label (effective September 1, 2026) does not name ethinyl estradiol/ferrous fumarate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ferrous fumarate/levonorgestrel | Rifabutin | |
|---|---|---|
| Labeled for | Birth control | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $3.45 per tablet 28 tablet | $8.14 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once