What the FDA labels say about taking them together
Ethinyl estradiol/ferrous fumarate/levonorgestrel and prednisolone
Ethinyl estradiol/ferrous fumarate/levonorgestrel's FDA label of October 18, 2024 names prednisolone in its drug interactions section; the prednisolone labels PlainMeds reads (4) do not name ethinyl estradiol/ferrous fumarate/levonorgestrel. The ethinyl estradiol/ferrous fumarate/levonorgestrel label: “Contraceptives on Other Drugs Combined oral contraceptives containing EE may inhibit the metabolism of other compounds and increase their plasma concentrations.”
Check it at the source: the ethinyl estradiol/ferrous fumarate/levonorgestrel FDA label on DailyMed (effective October 18, 2024, Xiromed, LLC); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the ethinyl estradiol/ferrous fumarate/levonorgestrel label say about prednisolone?
Ethinyl estradiol/ferrous fumarate/levonorgestrel label, drug interactionsContraceptives on Other Drugs Combined oral contraceptives containing EE may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Source: FDA drug label (Joyeaux), Xiromed, LLC, effective October 18, 2024 (SPL set 655b2c93-cfae-d44f-c128-c816bbd88e45), via openFDA; the full label on DailyMed
What does the prednisolone label say about ethinyl estradiol/ferrous fumarate/levonorgestrel?
Prednisolone's label (effective June 25, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/ferrous fumarate/levonorgestrel | Prednisolone | |
|---|---|---|
| Labeled for | Birth control | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $3.45 per tablet 28 tablet | $4.72 per mL 1% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once