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What the FDA labels say about taking them together

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel and rufinamide

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel's FDA label of January 9, 2025 names rufinamide in its drug interactions section; the rufinamide label PlainMeds reads does not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel. The ethinyl estradiol/ferrous bisglycinate/levonorgestrel label: “… felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.”

Check it at the source: the ethinyl estradiol/ferrous bisglycinate/levonorgestrel FDA label on DailyMed (effective January 9, 2025, Lupin Pharmaceuticals, Inc.); the rufinamide FDA label on DailyMed (effective December 15, 2022, Eisai Inc.).

What does the ethinyl estradiol/ferrous bisglycinate/levonorgestrel label say about rufinamide?

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel label, drug interactions

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.

Source: FDA drug label (MINZOYA), Lupin Pharmaceuticals, Inc., effective January 9, 2025 (SPL set d5ebd7fa-c388-4619-8dcb-e862e4ce5285), via openFDA; the full label on DailyMed

What does the rufinamide label say about ethinyl estradiol/ferrous bisglycinate/levonorgestrel?

Rufinamide's label (effective December 15, 2022) does not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Banzel), Eisai Inc., effective December 15, 2022 (SPL set 0a3fa925-1abd-458a-bd57-4ae780a1ef2d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

1Ethinyl estradiol/ferrous bisglycinate/levonorgestrel generic labelers
11Rufinamide generic labelers
Ethinyl estradiol/ferrous bisglycinate/levonorgestrelRufinamide
Labeled forBirth controln/a
Boxed warningYesNo
Pharmacy cost (NADAC)$3.45 per tablet 28 tablet$0.203 per mL 40 mg/mL suspension
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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