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What the FDA labels say about taking them together

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel and itraconazole

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel's FDA label of January 9, 2025 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel. The ethinyl estradiol/ferrous bisglycinate/levonorgestrel label: “CYP3A4 inhibitors, such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.”

Check it at the source: the ethinyl estradiol/ferrous bisglycinate/levonorgestrel FDA label on DailyMed (effective January 9, 2025, Lupin Pharmaceuticals, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).

What does the ethinyl estradiol/ferrous bisglycinate/levonorgestrel label say about itraconazole?

Ethinyl estradiol/ferrous bisglycinate/levonorgestrel label, drug interactions

CYP3A4 inhibitors, such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.

Source: FDA drug label (MINZOYA), Lupin Pharmaceuticals, Inc., effective January 9, 2025 (SPL set d5ebd7fa-c388-4619-8dcb-e862e4ce5285), via openFDA; the full label on DailyMed

What does the itraconazole label say about ethinyl estradiol/ferrous bisglycinate/levonorgestrel?

Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

1Ethinyl estradiol/ferrous bisglycinate/levonorgestrel generic labelers
11Itraconazole generic labelers
Ethinyl estradiol/ferrous bisglycinate/levonorgestrelItraconazole
Labeled forBirth controlFungal infections
Boxed warningYesYes
Pharmacy cost (NADAC)$3.45 per tablet 28 tablet$0.910 per capsule 100 mg capsule
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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