What the FDA labels say about taking them together
Ethinyl estradiol/etonogestrel and prednisolone
Ethinyl estradiol/etonogestrel's FDA label of November 14, 2025 names prednisolone in its drug interactions section; the prednisolone labels PlainMeds reads (4) do not name ethinyl estradiol/etonogestrel. The ethinyl estradiol/etonogestrel label: “Effects of CHCs on Other Drugs CHCs containing ethinyl estradiol may inhibit the metabolism of other compounds and increase their plasma concentrations.”
Check it at the source: the ethinyl estradiol/etonogestrel FDA label on DailyMed (effective November 14, 2025, Organon LLC); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the ethinyl estradiol/etonogestrel label say about prednisolone?
Ethinyl estradiol/etonogestrel label, drug interactionsEffects of CHCs on Other Drugs CHCs containing ethinyl estradiol may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Source: FDA drug label (NuvaRing), Organon LLC, effective November 14, 2025 (SPL set 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97), via openFDA; the full label on DailyMed
What does the prednisolone label say about ethinyl estradiol/etonogestrel?
Prednisolone's label (effective June 25, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/etonogestrel | Prednisolone | |
|---|---|---|
| Labeled for | Birth control | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $46.35 per ring Etonogestrel-ee vaginal ring | $4.72 per mL 1% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once