What the FDA labels say about taking them together
Ethinyl estradiol/etonogestrel and miconazole
Ethinyl estradiol/etonogestrel's FDA label of November 14, 2025 names miconazole in its drug interactions section; the miconazole labels PlainMeds reads (2) do not name ethinyl estradiol/etonogestrel. The ethinyl estradiol/etonogestrel label: “Co-administration of vaginal miconazole nitrate and NuvaRing increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40%.”
Check it at the source: the ethinyl estradiol/etonogestrel FDA label on DailyMed (effective November 14, 2025, Organon LLC); the miconazole FDA label on DailyMed (effective July 21, 2026, WALGREEN COMPANY).
What does the ethinyl estradiol/etonogestrel label say about miconazole?
Ethinyl estradiol/etonogestrel label, drug interactionsCo-administration of vaginal miconazole nitrate and NuvaRing increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40% [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (NuvaRing), Organon LLC, effective November 14, 2025 (SPL set 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97), via openFDA; the full label on DailyMed
What does the miconazole label say about ethinyl estradiol/etonogestrel?
Miconazole's label (effective July 21, 2026) and its 1 other brand-application label do not name ethinyl estradiol/etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Miconazole 3 Walgreen Company), NDA020670 (Medtech Products), as published by WALGREEN COMPANY, effective July 21, 2026 (SPL set 32b373be-9c8e-49b0-a796-8d87f6a20cef), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/etonogestrel | Miconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $46.35 per ring Etonogestrel-ee vaginal ring | $0.120 per gram 2% topical cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once