What the FDA labels say about taking them together
Darunavir and ethinyl estradiol/etonogestrel
Ethinyl estradiol/etonogestrel's FDA label of November 14, 2025 names darunavir in its drug interactions section; the darunavir label PlainMeds reads does not name ethinyl estradiol/etonogestrel. The ethinyl estradiol/etonogestrel label: “Human immunodeficiency virus (HIV) / Hepatitis C Virus (HCV) protease inhibitors and non-nucleoside reverse transcriptase inhibitors Significant changes in the plasma concentrations of the estrogen and /or progestin …”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the ethinyl estradiol/etonogestrel FDA label on DailyMed (effective November 14, 2025, Organon LLC).
What does the darunavir label say about ethinyl estradiol/etonogestrel?
Darunavir's label (effective August 29, 2025) does not name ethinyl estradiol/etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/etonogestrel label say about darunavir?
Ethinyl estradiol/etonogestrel label, drug interactionsHuman immunodeficiency virus (HIV) / Hepatitis C Virus (HCV) protease inhibitors and non-nucleoside reverse transcriptase inhibitors Significant changes in the plasma concentrations of the estrogen and /or progestin have been noted in some cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir]) /HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., efavirenz, nevirapine] or increase [e.g., etravirine]).
Source: FDA drug label (NuvaRing), Organon LLC, effective November 14, 2025 (SPL set 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Ethinyl estradiol/etonogestrel | |
|---|---|---|
| Labeled for | HIV | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $46.35 per ring Etonogestrel-ee vaginal ring |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once