What the FDA labels say about taking them together
Acetaminophen and ethinyl estradiol/etonogestrel
Ethinyl estradiol/etonogestrel's FDA label of November 14, 2025 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name ethinyl estradiol/etonogestrel. The ethinyl estradiol/etonogestrel label: “Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the ethinyl estradiol/etonogestrel FDA label on DailyMed (effective November 14, 2025, Organon LLC).
What does the acetaminophen label say about ethinyl estradiol/etonogestrel?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name ethinyl estradiol/etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/etonogestrel label say about acetaminophen?
Ethinyl estradiol/etonogestrel label, drug interactionsAscorbic acid and acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
Source: FDA drug label (NuvaRing), Organon LLC, effective November 14, 2025 (SPL set 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Ethinyl estradiol/etonogestrel | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | $46.35 per ring Etonogestrel-ee vaginal ring |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once