What the FDA labels say about taking them together
Estradiol/norethindrone and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names estradiol/norethindrone in its drug interactions section; the estradiol/norethindrone labels PlainMeds reads (2) do not name fosamprenavir. The fosamprenavir label: “Oral contraceptives: Ethinyl estradiol/norethindrone Fosamprenavir: ↓ Amprenavir ↓ Ethinyl estradiol Alternative methods of non-hormonal contraception are recommended.”
Check it at the source: the estradiol/norethindrone FDA label on DailyMed (effective January 16, 2025, Amneal Pharmaceuticals NY LLC); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the estradiol/norethindrone label say about fosamprenavir?
Estradiol/norethindrone's label (effective January 16, 2025) and its 1 other brand-application label do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LOPREEZA), Amneal Pharmaceuticals NY LLC, effective January 16, 2025 (SPL set 966ac064-9eb7-4d15-b271-a7880ed1e79a), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about estradiol/norethindrone?
Fosamprenavir label, drug interactionsOral contraceptives: Ethinyl estradiol/norethindrone Fosamprenavir: ↓ Amprenavir ↓ Ethinyl estradiol Alternative methods of non-hormonal contraception are recommended.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estradiol/norethindrone | Fosamprenavir | |
|---|---|---|
| Labeled for | Menopause symptoms, Osteoporosis | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.802 per tablet 0.5-0.1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once