What the FDA labels say about taking them together
Estradiol and testosterone
Estradiol's FDA label of April 3, 2024 names testosterone in its warnings and precautions section; the testosterone labels PlainMeds reads (4) do not name estradiol. The estradiol label: “Free hormone concentrations, such as testosterone and estradiol, may be decreased.”
Check it at the source: the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC); the testosterone FDA label on DailyMed (effective July 25, 2025, Azurity Pharmaceuticals, Inc.).
What does the estradiol label say about testosterone?
Estradiol label, warnings and precautionsFree hormone concentrations, such as testosterone and estradiol, may be decreased.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
What does the testosterone label say about estradiol?
Testosterone's label (effective July 25, 2025) and its 3 other brand-application labels do not name estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AZMIRO), Azurity Pharmaceuticals, Inc., effective July 25, 2025 (SPL set 235b5625-570d-3fba-e063-6394a90aa2d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estradiol | Testosterone | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | Breast cancer |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0635 per tablet 1 mg tablet | $11.39 per mL 200 mg/mL |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once