What the FDA labels say about taking them together
Estradiol and histrelin
Histrelin's FDA label of September 25, 2025 names estradiol in its warnings and precautions section; the estradiol labels PlainMeds reads (4) do not name histrelin. The histrelin label: “WARNINGS AND PRECAUTIONS Initial Agnostic Action: Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms.”
Check it at the source: the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC); the histrelin FDA label on DailyMed (effective September 25, 2025, Endo USA, Inc.).
What does the estradiol label say about histrelin?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name histrelin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
What does the histrelin label say about estradiol?
Histrelin label, warnings and precautionsWARNINGS AND PRECAUTIONS Initial Agnostic Action: Initial transient increases of estradiol and/or testosterone may cause a temporary worsening of symptoms ( 5.1 ).
Source: FDA drug label (SUPPRELIN LA), Endo USA, Inc., effective September 25, 2025 (SPL set d8fb000e-3cc9-4803-b71d-2cc597661977), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estradiol | Histrelin | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0635 per tablet 1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once