What the FDA labels say about taking them together
Estradiol and estrogens conjugated
Estrogens conjugated's FDA label of June 4, 2026 names estradiol in its warnings and precautions section; the estradiol labels PlainMeds reads (4) do not name estrogens conjugated. The estrogens conjugated label: “Free hormone concentrations, such as testosterone and estradiol, may be decreased.”
Check it at the source: the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC); the estrogens conjugated FDA label on DailyMed (effective June 4, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.).
What does the estradiol label say about estrogens conjugated?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name estrogens conjugated in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
What does the estrogens conjugated label say about estradiol?
Estrogens conjugated label, warnings and precautionsFree hormone concentrations, such as testosterone and estradiol, may be decreased.
Source: FDA drug label (Premarin), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective June 4, 2026 (SPL set 258e1602-a3cf-4ccc-ca80-73dbbfb812ff), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estradiol | Estrogens conjugated | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | Menopause symptoms, Breast cancer, Osteoporosis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0635 per tablet 1 mg tablet | $5.47 per tablet 0.625 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once