What the FDA labels say about taking them together
Estazolam and rifampin
Estazolam's FDA label of November 11, 2022 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name estazolam. The estazolam label: “While no in vivo drug-drug interaction studies were conducted between estazolam and inducers of CYP3A, compounds that are potent CYP3A inducers would be expected to decrease estazolam concentrations.”
Check it at the source: the estazolam FDA label on DailyMed (effective November 11, 2022, Novitium Pharma LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the estazolam label say about rifampin?
Estazolam label, drug interactionsWhile no in vivo drug-drug interaction studies were conducted between estazolam and inducers of CYP3A, compounds that are potent CYP3A inducers (such as carbamazepine, phenytoin, rifampin, and barbiturates) would be expected to decrease estazolam concentrations.
Source: FDA drug label (Estazolam), Novitium Pharma LLC, effective November 11, 2022 (SPL set e1c77eb1-9cba-4e89-a03f-9fb797add4f0), via openFDA; the full label on DailyMed
What does the rifampin label say about estazolam?
Rifampin's label (effective February 11, 2026) does not name estazolam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estazolam | Rifampin | |
|---|---|---|
| Labeled for | Insomnia | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.839 per tablet 2 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once