What the FDA labels say about taking them together
Eslicarbazepine and simvastatin
Eslicarbazepine's FDA label of November 10, 2023 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name eslicarbazepine. The eslicarbazepine label: “In vivo studies suggest that APTIOM can induce CYP3A4, decreasing plasma concentrations of drugs that are metabolized by this isoenzyme.”
Check it at the source: the eslicarbazepine FDA label on DailyMed (effective November 10, 2023, Sumitomo Pharma America, Inc.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the eslicarbazepine label say about simvastatin?
Eslicarbazepine label, drug interactionsIn vivo studies suggest that APTIOM can induce CYP3A4, decreasing plasma concentrations of drugs that are metabolized by this isoenzyme (e.g., simvastatin, lovastatin) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Aptiom), Sumitomo Pharma America, Inc., effective November 10, 2023 (SPL set 3d0c9554-eaeb-4694-8089-00133fcadce3), via openFDA; the full label on DailyMed
What does the simvastatin label say about eslicarbazepine?
Simvastatin's label (effective March 28, 2025) does not name eslicarbazepine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eslicarbazepine | Simvastatin | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.68 per tablet 200 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once