What the FDA labels say about taking them together
Esketamine and modafinil
Esketamine's FDA label of March 31, 2026 names modafinil in its drug interactions section; the modafinil label PlainMeds reads does not name esketamine. The esketamine label: “Concomitant use with psychostimulants may increase blood pressure.”
Check it at the source: the esketamine FDA label on DailyMed (effective March 31, 2026, Janssen Pharmaceuticals, Inc.); the modafinil FDA label on DailyMed (effective October 16, 2025, Golden State Medical Supply, Inc.).
What does the esketamine label say about modafinil?
Esketamine label, drug interactionsConcomitant use with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) may increase blood pressure [see Warnings and Precautions (5.7) ].
Source: FDA drug label (Spravato), Janssen Pharmaceuticals, Inc., effective March 31, 2026 (SPL set d81a6a79-a74a-44b7-822c-0dfa3036eaed), via openFDA; the full label on DailyMed
What does the modafinil label say about esketamine?
Modafinil's label (effective October 16, 2025) does not name esketamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Provigil), NDA020717 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective October 16, 2025 (SPL set 3b8d1c32-dac9-50e6-e063-6394a90aa5a5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esketamine | Modafinil | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $429.98 per unit 84 mg dose pack | $0.344 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once