What the FDA labels say about taking them together
Esketamine and methylphenidate
Esketamine's FDA label of March 31, 2026 names methylphenidate in its drug interactions section; the methylphenidate labels PlainMeds reads (4) do not name esketamine. The esketamine label: “Concomitant use with psychostimulants may increase blood pressure.”
Check it at the source: the esketamine FDA label on DailyMed (effective March 31, 2026, Janssen Pharmaceuticals, Inc.); the methylphenidate FDA label on DailyMed (effective July 31, 2026, Lannett Company, LLC).
What does the esketamine label say about methylphenidate?
Esketamine label, drug interactionsConcomitant use with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) may increase blood pressure [see Warnings and Precautions (5.7) ].
Source: FDA drug label (Spravato), Janssen Pharmaceuticals, Inc., effective March 31, 2026 (SPL set d81a6a79-a74a-44b7-822c-0dfa3036eaed), via openFDA; the full label on DailyMed
What does the methylphenidate label say about esketamine?
Methylphenidate's label (effective July 31, 2026) and its 3 other brand-application labels do not name esketamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (methylphenidate hydrochloride CD), Lannett Company, LLC, effective July 31, 2026 (SPL set e45c75dc-d381-475b-b649-a871c8a36e60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esketamine | Methylphenidate | |
|---|---|---|
| Labeled for | n/a | ADHD |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $429.98 per unit 84 mg dose pack | $0.158 per tablet 10 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once