What the FDA labels say about taking them together
Erythromycin and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name rilpivirine. The rilpivirine label: “Macrolides are expected to increase concentrations of rilpivirine and are associated with a risk of Torsade de Pointes [Warnings and Precautions]. …”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the erythromycin label say about rilpivirine?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the rilpivirine label say about erythromycin?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Macrolide or ketolide antibiotics: azithromycin clarithromycin erythromycin; Effect on Concentration of Rilpivirine or Concomitant Drug: ↑ rilpivirine ↔ azithromycin ↔ clarithromycin ↔ erythromycin; Clinical Comment: Macrolides are expected to increase concentrations of rilpivirine and are associated with a risk of Torsade de Pointes [Warnings and Precautions (5.4)]. Where possible, consider alternatives, such as azithromycin, which increases rilpivirine concentrations less than other macrolides.
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Rilpivirine | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once