What the FDA labels say about taking them together
Erythromycin and naloxegol
Naloxegol's FDA label of September 1, 2026 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name naloxegol. The naloxegol label: “•Avoid use with moderate CYP3A4 inhibitors; if unavoidable, decrease the dosage of MOVANTIK to 12.5 mg once daily and monitor for adverse reactions.”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.).
What does the erythromycin label say about naloxegol?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the naloxegol label say about erythromycin?
Naloxegol label, drug interactionsConcomitant Agent: •Moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil); Mechanism of Action: •Increase plasma naloxegol concentrations and may increase the risk of adverse reactions [see ].; Clinical Recommendation: •Avoid use with moderate CYP3A4 inhibitors; if unavoidable, decrease the dosage of MOVANTIK to 12.5 mg once daily and monitor for adverse reactions [see ].
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Naloxegol | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $14.61 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once