What the FDA labels say about taking them together
Erythromycin and fluconazole
Fluconazole's FDA label of April 7, 2026 names erythromycin in its contraindications section; the erythromycin labels PlainMeds reads (4) do not name fluconazole. The fluconazole label: “Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole. …”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the erythromycin label say about fluconazole?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the fluconazole label say about erythromycin?
Fluconazole label, contraindicationsCoadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole. ( See CLINICAL PHARMACOLOGY:
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Fluconazole | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once